Three distinct 3-methylcytidine (mC) methyltransferases modify tRNA and mRNA in mice and humans
نویسندگان
چکیده
X Luang Xu, Xinyu Liu, Na Sheng, Kyaw Soe Oo, Junxin Liang, Yok Hian Chionh , Juan Xu, Fuzhou Ye**, Yong-Gui Gao**, Peter C. Dedon , and Xin-Yuan Fu From the Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, 117599 Singapore, the Model Animal Research Center of Nanjing University, 12 Xuefu Road, 210032 Nanjing, China, the Department of Biochemistry, National University of Singapore, 8 Medical Drive, 117596 Singapore, the Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, 138602 Singapore, the **School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore, and the Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
منابع مشابه
Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.
Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. Despite a resurgent interest in these modifications, the biochemistry of 3-methylcytidine (m3C) formation in mammalian RNAs is still poorly understood. However, the rec...
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Ever since the first RNA nucleoside modification was characterized in 1957 [1], over 100 distinct chemical modifications have been identified in RNA to date [2]. Most of these modifications were characterized in non-coding RNAs (ncRNAs), including tRNA, rRNA, and small nuclear RNA (snRNA) [3]. Studies in the past few decades have located various modifications in these ncRNAs and revealed their ...
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